CYSTC: Cystatin C: Cystatin C is a low molecular weight 13,250 kD cysteine proteinase inhibitor that is produced by all nucleated cells and found in body fluids, including serum. Since it is formed at a constant rate and freely filtered by the kidneys, its serum concentration is inversely correlated with the glomerular filtration rate GFR. Estimating glomerular filtration rate from serum creatinine and cystatin C_医药卫生_专业资料 73人阅读9次下载. Estimating glomerular filtration rate from serum creatinine and cystatin C_医药卫生_专业资料。The n e w e ng l a n d j o u r na l of m e dic i n e original article Estimating Glomerular Fil. 2013-12-02 · Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS: Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012, 367: 20-29. 2012-04-01 · Estimation of Glomerular Filtration Rate From Serum Cystatin C and Creatinine in Patients with Thyroid Dysfunction. Given that thyroid function influences serum cystatin C and creatinine levels, the question arises as to whether it is possible to accurately estimate glomerular filtration rate GFR in patients with thyroid dysfunction.
Estimating Glomerular Filtration Rate n engl j med 367;1july 5, 2012 21 C linical assessment of kidney func-tion is part of routine medical care for adults.1 More than 80% of clinical laborato-ries now report an estimated glomerular filtration rate GFR when serum creatinine is measured.2 Despite standardization of serum creatinine as Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease Andrew D. Rule1, Kent R. Bailey2, John C. Lieske3, Patricia A. Peyser4 and Stephen T. Turner5. Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease Author links open overlay panel Andrew D. Rule 1 Kent R. Bailey 2 John C. Lieske 3 Patricia A. Peyser 4 Stephen T. Turner 5. TY - JOUR. T1 - Estimating glomerular filtration rate from serum creatinine and cystatin C. AU - Inker, Lesley A. AU - Schmid, Christopher H. AU - Tighiouart, Hocine. 2013-12-02 · Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS: Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012, 367: 20-29..
Blood concentration of cystatin C is independent of muscle mass and tubular secretion. It can be used, in the absence of a reference method, as an alternative marker to creatinine for the evaluation of renal function and the estimation of glomerular filtration rate GFR. Skip to Main Content. This Journal; Anywhere. RESEARCH ARTICLE Open Access Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians Marcelo B Lopes1, Lara Q Araújo2, Michelle T Passos1, Sonia K Nishida1, Gianna M Kirsztajn1. 2012-07-01 · Vinge E, Lindergård B, Nilsson-Ehle P, Grubb A. Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults. Scand J Clin Lab Invest. 1999; 59:587–92.
2017-04-01 · Creatinine, the most commonly used endogenous marker of glomerular filtration rate GFR,4 has in recent years been supplemented by cystatin C. In fact, today's most reliable equations for estimating GFR both in adults 1 and in children 2 make use of a combination of the 2. Glomerular filtration rate GFR is the best overall index of kidney function. Normal GFR varies according to age, sex, and body size, and declines with age. The National Kidney Foundation recommends using the CKD-EPI Creatinine Equation 2009 to estimate GFR. Estimating Glomerular Filtration Rate in Kidney Transplantation: A Comparison between Serum Creatinine and Cystatin C–Based Methods Christine White, Ayub Akbari,† Naser Hussain, Laurent Dinh,‡ Guido Filler,§. 2008-01-01 · Kyhse-Andersen J Schmidt C Nordin G Andersson B Nilsson-Ehle P Lindstrom V. Serum cystatin C determined by a rapid automated particle-enhanced turbidimetric method is a better marker than serum creatinine for glomerular filtration rate. Clin Chem 1994; 40: 1921-6. Hoeck FJ Kemperman FA Krediet RT.
Cystatin C: An index of glomerular filtration rate, especially in patients where serum creatinine may be misleading eg, very obese, elderly, or malnourished patients Assessing renal function in patients suspected of having kidney disease Monitoring treatment response in patients with kidney disease Estimated Glomerular Filtration Rate eGFR. Distribution of serum cystatin C Cys C levels in the study population n = 1246. The proportion of individuals at each serum Cys C level having a glomerular filtration rate GFR in the ranges indicated is calculated using the Modification of Diet in Renal Disease Study. Estimating glomerular filtration rate in diabetes A comparison of cystatin-C- and creatinine-based methods. R. J. MacIsaac, C. Tsalamandris, M. C. Thomas,. Abstract. Aims/hypothesis: We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes. Subjects. Estimating GFR by Serum Creatinine, Cystatin C,. et al.Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int, 75 2009, pp. 652-660. et al.Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility.
If kidney function and glomerular filtration rate decline, the blood levels of cystatin C rise. Cross-sectional studies based on a single point in time suggest that serum levels of cystatin C are a more precise test of kidney function as represented by the glomerular filtration rate, GFR than serum creatinine levels. Chronic kidney disease risk factors may associate with the estimated glomerular filtration rate eGFR differently than with the measured GFR. To examine this, we evaluated 1150 patients mean age 65 years in two community cohorts for risk factors, measured GFR by iothalamate clearance, and eGFR based on creatinine Cr, cystatin C CysC, or.
2017-10-05 · Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort Jonas Björk Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden.
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